A Viable Alternative to Lipid Nanoparticles
At Organix, we're excited to introduce the groundbreaking potential of polymer nanoparticles (PNPs) as an alternative to lipid nanoparticles for mRNA encapsulation. These dynamic particles serve the same vital role as drug delivery systems in nanotechnology, but with possibly lower toxicity and less potential for accumulation in the liver. Our expertise in polymers for use in polymer nanoparticles (PNP) underpins our purification and characterization services, employing polymer characterization techniques such as Tangential Flow Chromatography (TFF), Gel Permeation Chromatography (GPC), and Size Exclusion Chromatography (SEC) to deliver pure, high quality results. Now available GMP grade also.
Our Methods
TFF
Drying Methods
GPC
Characterization
Polymer Nanoparticles for Drug Delivery
Polymer nanoparticle characterization is integral to understanding the advancements in drug delivery innovations and polymer nanomedicine. The applications of polymer-based nanoparticles for smart drug delivery highlight the intersection of nanomedicine advancements and the practical utilization of polymer nanoparticle applications. These developments collectively contribute to the evolving landscape of innovative drug delivery strategies in the field.
However, successful clinical translation relies on rigorous characterization to establish Critical Quality Attributes (CQAs) early. By pinpointing precise molecular weight distributions and achieving ultra-narrow polydispersity (PDI), our characterization efforts help clients eliminate the batch-to-batch variability that often stalls nanoparticle innovations. To further support your regulatory success, these materials are now available in GMP grade.
Polymer Nanomedicine Innovations
At Organix, we act as your expert 'lab next door,' serving as passionate pioneers in the exciting and still largely unexplored field of novel polymer development. We do not directly manufacture nanoparticles, but specialize in producing the precision-engineered essential building blocks for the formation of polymer nanoparticles used in encapsulation of mRNA and single-strand-interfering DNA (ssDNA).
Our PhD-led expertise in radical polymerization extends to the polymerization of N-(2-hydroxypropyl)methacrylamide (HPMA) conjugates and the utilization of various initiators and chain transfer agents, allowing a complete gamut of Reversible Deactivation Radical Polymerization (RDRP) methods, such as reversible addition−fragmentation chain-transfer (RAFT) polymerization. Mastering these techniques allows us to strictly dictate block lengths and achieve the mathematical precision required to lock in structural integrity and scale seamlessly from milligram research batches to multi-kilogram production.
Reach Out to Our Experts
Custom Synthesis
(GMP lipids now available)
We provide custom synthesis of molecules in all structural classes, design and synthesis and of New Chemical Entities (NCE), Structure Activity Relationship (SAR) studies, Hit-to-Lead studies, and development and optimization of synthetic procedures. We also design and synthesize phosphoramidites and drug conjugates in which active NCEs are tethered to HRP, PEG, HPMA-polymers, HPMA-copolymers, or other large molecules such as GalNAc dendrimers. These tethered NCEs can also be designed to cleave and release the NCE in situ.
Contract R&D
Organix, a Symeres company is your partner for contract research and development in all areas of organic and medicinal chemistry. Our mission is to provide services that meet or exceed the services that you may have available in-house. We approach every partnership with complete transparency and decades of specialized chemistry experience. This collaborative foundation allows us to act as a true extension of your own lab—reacting instantly to solve complex challenges the moment your project demands shift.